TY - CHAP M1 - Book, Section TI - Precocious Puberty A1 - Soriano-Guillén, Leandro A1 - Sarafoglou, Kyriakie A1 - Argente, Jesús A2 - Sarafoglou, Kyriakie A2 - Hoffmann, Georg F. A2 - Roth, Karl S. Y1 - 2017 N1 - T2 - Pediatric Endocrinology and Inborn Errors of Metabolism, 2e AB - Normal pubertal development is dependent on a change in the activity of the hypothalamic-pituitary-gonadal (HPG) axis from a period of relative quiescence during childhood to its reactivation during puberty. Any disruption to the normal inhibition of this axis during childhood results in central precocious puberty. Alternatively, secretion of or exposure to sex steroids independent of this axis can result in a peripheral form of precocious puberty. The challenge to the practitioner is to identify children with pathologic forms of precocious puberty and determine whether the etiology is central (gonadotropin-releasing hormone [GnRH]-dependent) or peripheral (GnRH-independent) in order to initiate appropriate therapy. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1140320372 ER -