TY - CHAP M1 - Book, Section TI - Delayed Puberty, Boys A1 - Hay, Jr, William W. A1 - Levin, Myron J. A1 - Deterding, Robin R. A1 - Abzug, Mark J. Y1 - 2017 N1 - T2 - Quick Medical Diagnosis & Treatment Pediatrics AB - Indications for evaluationNo secondary sexual characteristics by 14 years of ageMore than 5 years have elapsed since the first signs of puberty without completion of genital growthMost common cause is constitutional growth delayHypogonadism in boys may be classified asPrimary due to absence, malfunction, or destruction of testicular tissueCentral due to pituitary or hypothalamic insufficiencyPrimary testicular insufficiency may be due toAnorchiaKlinefelter syndrome (47,XXY) or other sex chromosome abnormalitiesEnzymatic defects in testosterone synthesisInflammation or destruction of the testes following infection (mumps), autoimmune disorders, radiation, trauma, or tumorCentral hypogonadism may accompanyPanhypopituitarismHypogonadotropic hypogonadism with (Kallmann syndrome) or without abnormalities in smellHyperprolactinemiaIsolated luteinizing hormone (LH) or follicle-stimulating hormone (FSH) deficiencyDestructive lesions in or near the anterior pituitary (especially craniopharyngioma and glioma)InfectionPrader-Willi syndromeLaurence-Moon syndrome (Bardet-Biedl syndrome)Deficiencies in gonadotropins may be partial or completeFunctional or reversible gonadotropin may occur with chronic illness, malnutrition, hyperprolactinemia, hypothyroidism, or excessive exercise SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/13 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1145454999 ER -