TY - CHAP M1 - Book, Section TI - Autoimmune Disorders of the Liver A1 - Karam, Lina Boujaoude A2 - Kline, Mark W. Y1 - 2018 N1 - T2 - Rudolph's Pediatrics, 23e AB - Autoimmune liver disorders result from a spectrum of immune dysregulation where the liver can be the only organ affected or may be part of a systemic multiorgan disorder with the inflammatory response being mediated by systemic or locally produced (portal system) cytokines. The immunogenic target varies and may include the liver parenchyma, bile duct epithelium, or vasculature, with overlap syndromes that include both biliary and parenchymal involvement being increasingly recognized among children. Clinical manifestations vary depending upon the pattern of involvement. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/14 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182909004 ER -