TY - CHAP M1 - Book, Section TI - Drug-Associated Rashes A1 - DeKlotz, Cynthia M.C. A1 - Eichenfield, Lawrence F. A2 - Zaoutis, Lisa B. A2 - Chiang, Vincent W. Y1 - 2017 N1 - T2 - Comprehensive Pediatric Hospital Medicine, 2e AB - Drug-associated rashes are very common in hospitalized patients, and uncommonly can be associated with conditions that prompt admission. In large prospective studies and systematic reviews, 2.9% to 4% of pediatric hospital admissions were related to adverse drug reactions.1,2 The Boston Drug Surveillance Project estimated that approximately 30% of hospitalized patients experience adverse drug events,3 and in 1991 the Harvard Medical Practice Study II published data showing that drug events were the most common type of adverse event in the hospital.4 Pediatric adverse drug reaction rates were estimated in a large systematic review at 0.6% to 16.8% of all children exposed to drugs during a hospital stay.2 A study in the 1980s in New York state estimated that as many as 20% of serious drug reactions involve the skin. Certain categories of common pediatric medications, including antibiotics and anticonvulsants, are associated with rates of drug eruption ranging from as high as 1% to 5%.5 Many unique cutaneous reaction patterns have been described, and the same medication may cause different reaction patterns in different patients, thus making accurate diagnosis challenging. A subset of drug eruptions are serious and may even be life threatening and require rapid diagnosis and intervention. Therefore it is important in the inpatient setting to be able to recognize the common patterns of cutaneous drug reaction, identify the probable causative agent, and institute appropriate therapy when indicated. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1146115852 ER -