TY - CHAP M1 - Book, Section TI - Disorders of the Adrenal Gland A1 - Roizen, Jeffrey D. A1 - Palladino, Andrew A. A2 - Zaoutis, Lisa B. A2 - Chiang, Vincent W. Y1 - 2017 N1 - T2 - Comprehensive Pediatric Hospital Medicine, 2e AB - The adrenal gland is responsible for producing two kinds of signaling molecules: steroid hormones, produced in the outer adrenal cortex, and catecholamines, generated in the adrenal medulla. Steroids can further be divided into mineralocorticoid (aldosterone), glucocorticoid (cortisol) and androgen (dehydroepiandrosterone [DHEA] and dehydroepiandrosterone-sulfate [DHEA-S]) classes. Each of these steroids is stereotypically produced by histologically differentiable cells in a particular layer of the adrenal cortex—the outermost zona glomerulosa produces aldosterone, the middle zona fasciculata produces cortisol, and the innermost zona reticularis produces DHEA and DHEA-S. Control of steroid hormone production and release, however, occurs outside of the adrenal gland; aldosterone is primarily controlled by the renin-angiotensin system and cortisol is regulated by adrenocorticotropic hormone (ACTH) from the pituitary gland, which itself is regulated by hypothalamic secretion of corticotropin-releasing hormone (CRH). Although DHEA-S is the most abundant androgen in serum, the control and function of DHEA and DHEA-S are less well understood. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1146116511 ER -