TY - CHAP M1 - Book, Section TI - Interstitial Nephritis A1 - Ganem, Jorge F. A2 - Zaoutis, Lisa B. A2 - Chiang, Vincent W. Y1 - 2017 N1 - T2 - Comprehensive Pediatric Hospital Medicine, 2e AB - Interstitial nephritis was first described histologically in 1898 in the kidneys of patients who died from diphtheria and scarlet fever.1 Interstitial nephritis is characterized by histologic changes due to infiltration of the renal interstitium and tubular cells by inflammatory cells accompanied by interstitial edema or fibrosis and varying degrees of tubular atrophy. These inflammatory changes usually spare the glomeruli and renal vasculature. Interstitial nephritis is now termed tubulointerstitial nephritis (TIN). Acute TIN refers to acute renal dysfunction and is usually reversible. Common types of acute TIN include drug induced, infectious, immune mediated, and idiopathic. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/03 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1146119871 ER -