TY - CHAP M1 - Book, Section TI - Withdrawal Syndromes A1 - Hoffman, Robert J. A1 - Sharma, Adhi N. A2 - Zaoutis, Lisa B. A2 - Chiang, Vincent W. Y1 - 2017 N1 - T2 - Comprehensive Pediatric Hospital Medicine, 2e AB - Drug withdrawal is a physiologic response to an effectively lowered drug concentration in a patient tolerant to the drug in question. Withdrawal results in a predictable constellation of symptoms that are reversible if the drug is reintroduced. Withdrawal is a phenomenon of altered neurochemistry, and the central nervous system (CNS) is the most consequential target. Under normal conditions, the CNS maintains a balance between excitation and inhibition. Although such balance can be achieved by several means, excitation is constant and actions occur through removal of inhibitory tone.1 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/03 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1146123968 ER -