TY  - CHAP
M1  - Book, Section
TI  - Anticoagulants and Antithrombotics
A1  - Levine, Michael
A2  - Zaoutis, Lisa B.
A2  - Chiang, Vincent W.
Y1  - 2017
N1  - 
T2  - Comprehensive Pediatric Hospital Medicine, 2e
AB  - Under  normal  homeostatic  conditions,  the  human  body  is  at  a  constant  balance  between  clot  formation  and  destruction.  Physiologic  hemostasis  occurs  as  a  result  of  a  complex  interaction  among  platelets,  the  vascular  endothelium,  the  coagulation  cascade,  and  the  fibrinolytic  system.  Any  disorder  or  xenobiotic  that  alters  this  equilibrium  can  produce  either  excessive  thrombosis  or  hemorrhage.  Numerous  pharmacologic  agents  have  been  developed  to  prevent  thrombus  formation  by  interfering  with  platelet  adhesion  or  aggregation,  or  by  interfering  with  the  clotting  cascade.  Numerous  additional  drugs,  including  those  working  by  novel  mechanisms,  are  in  various  stages  of  development.1  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/23
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1146124493
ER  -