TY  - CHAP
M1  - Book, Section
TI  - Development of the Cardiovascular System
A1  - Srivastava, Deepak
A2  - Kline, Mark W.
Y1  - 2018
N1  - 
T2  - Rudolph's Pediatrics, 23e
AB  - Cardiogenesis  involves  a  precisely  orchestrated  series  of  molecular  and  morphogenetic  events  that  combines  cell  types  from  multiple  lineages.  Subtle  perturbations  of  this  process  can  result  in  life-threatening  congenital  heart  defects  (CHDs).  As  an  organ  essential  for  life,  the  heart  is  the  first  organ  to  form  and  must  support  the  rapidly  growing  embryo  before  it  has  the  opportunity  to  become  a  four-chambered  organ.  The  combination  of  the  complex  morphogenetic  events  necessary  for  cardiogenesis  and  the  superimposed  hemodynamic  influences  may  contribute  to  the  exquisite  sensitivity  of  the  heart  to  perturbations  as  reflected  in  the  estimated  10%  incidence  of  severe  cardiac  malformations  observed  in  early  miscarriages.  The  fraction  of  congenital  heart  malformations  that  are  compatible  with  development  composes  the  spectrum  of  CHD  observed  clinically  in  nearly  1%  of  live  births.  An  additional  1%  to  2%  of  the  population  harbor  more  subtle  cardiac  developmental  anomalies  that  only  become  apparent  as  age-dependent  phenomena  reveal  the  underlying  pathology.  A  more  precise  understanding  of  the  causes  of  CHD  is  imperative  for  the  recognition  and  potential  intervention  of  progressive  degenerative  conditions,  such  as  heart  failure,  among  survivors  of  CHD.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1182913364
ER  -