TY  - CHAP
M1  - Book, Section
TI  - Disorders of Purine and Pyrimidine Metabolism
A1  - El-Hattab, Ayman W.
A1  - Scaglia, Fernando
A2  - Kline, Mark W.
Y1  - 2018
N1  - 
T2  - Rudolph's Pediatrics, 23e
AB  - Purines  (adenine  and  guanine)  and  pyrimidines  (thymine,  cytosine,  and  uracil)  are  nitrogenous  bases  that  are  essential  components  of  nucleotides.  The  addition  of  pentose  monosaccharide  (ribose  or  deoxyribose)  to  a  base  results  in  a  nucleoside,  which  can  be  a  ribonucleoside  (adenosine,  guanosine,  cytidine,  and  uridine)  or  a  deoxyribonucleoside  (deoxyadenosine,  deoxyguanosine,  deoxycytidine,  and  thymidine).  Nucleotides  result  from  the  binding  of  nucleosides  to  phosphate.  The  binding  of  a  nucleoside  to  1,  2,  or  3  phosphate  groups  produces  nucleoside  mono-,  di-,  or  triphosphate,  respectively.  Nucleotides  are  essential  for  all  cells.  In  addition  to  their  vital  role  as  building  blocks  for  DNA  and  RNA,  they  serve  as  carriers  of  activated  intermediates  in  the  synthesis  of  a  variety  of  complex  molecules,  structural  components  of  several  essential  coenzymes,  messengers  in  signal  transduction  pathways,  regulatory  components  for  many  of  the  metabolic  pathways,  and  currency  for  energy  transfer  in  cells.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/16
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1182930379
ER  -