TY - CHAP M1 - Book, Section TI - Herpes Simplex Virus Infections A1 - Poole, Claudette L. A1 - Kimberlin, David W. A2 - Kline, Mark W. Y1 - 2018 N1 - T2 - Rudolph's Pediatrics, 23e AB - Herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) are 2 of the 8 members of the human herpesvirus family. Along with varicella-zoster virus (VZV), HSV-1 and HSV-2 belong to the alpha-herpesvirus subfamily and share the characteristic neurotropism and establishment of latency in sensory ganglia, with lifelong infection, periodic reactivation, and reappearance of infectious virus at mucocutaneous sites. Clinical manifestations when present can range from minor mucocutaneous vesicles to hemorrhagic encephalitis or disseminated disease, but most persons infected with either HSV-1 or HSV-2 are asymptomatic (Table 304-1). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/20 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182903284 ER -