TY - CHAP M1 - Book, Section TI - Disorders of the Epidermis A1 - Holland, Kristen E. A1 - Boulos, Scarlett A2 - Kline, Mark W. Y1 - 2018 N1 - T2 - Rudolph's Pediatrics, 23e AB - Primary skin diseases that principally affect the epidermis may be categorized as either a dermatitis or a papulosquamous disorder. Dermatitis commonly denotes inflammation of the epidermis. Eczema generically denotes edema within the epidermis. Many primary dermatitides are eczematous in nature, although the term eczema is often misused interchangeably for atopic dermatitis (AD). In its mildest or chronic form, edema is seen histopathologically as prominent, tooth-like interconnections between keratinocytes (spongiosis). With more intracellular fluid accumulation, intraepidermal vesicles are formed. Vesicles are often subclinical in subacute or chronic eczemas where edema is mild but present as grossly evident vesicles and bullae in acute eczemas. Papulosquamous eruptions are characterized by the presence of erythematous papules or plaques with overlying scale. While eczematous processes clinically manifest with weeping or crusting, papulosquamous disorders are associated with little to no edema and thus clinically tend to be dry. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/14 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182905132 ER -