TY - CHAP M1 - Book, Section TI - Cystic Fibrosis A1 - Saddi, Vishal A1 - Ooi, Chee Y. A1 - Jaffe, Adam A2 - Kline, Mark W. Y1 - 2018 N1 - T2 - Rudolph's Pediatrics, 23e AB - Cystic fibrosis (CF) is the most common lethal genetic condition in the Caucasian population. Significant progress has been made in diagnosis and treatment, which has led to dramatically increased survival and reduced morbidity rates. The localization of the gene encoding the CF transmembrane conductance regulator (CFTR) in 1989 enabled a deeper understanding of the disease pathophysiology and led to the development of novel therapeutic avenues correcting the basic defect instead of fire-fighting the downstream consequences of the disease. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182917191 ER -