TY - CHAP M1 - Book, Section TI - Isoniazid A1 - Lu, Jenny J. A2 - Tenenbein, Milton A2 - Macias, Charles G. A2 - Sharieff, Ghazala Q. A2 - Yamamoto, Loren G. A2 - Schafermeyer, Robert Y1 - 2019 N1 - T2 - Strange and Schafermeyer's Pediatric Emergency Medicine, 5e AB - Isoniazid (INH) toxicity should be considered in any patient with metabolic acidosis and seizures refractory to conventional therapy.Altered sensorium, slurred speech, ataxia, coma, and seizures can occur rapidly after an INH overdose.INH toxicity is associated with profound metabolic acidosis and increased serum lactate.The antidote for INH poisoning is pyridoxine (vitamin B6). Administer an amount of pyridoxine equivalent to the amount of INH ingested on a gram-for-gram basis. If the ingested dose is unknown, administer 70 mg/kg (up to a total of 5.0g) and repeat if seizures persist. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1155749051 ER -