TY - CHAP M1 - Book, Section TI - Alkaptonuria (AKU) A1 - Bissonnette, Bruno A1 - Luginbuehl, Igor A1 - Engelhardt, Thomas Y1 - 2019 N1 - T2 - Syndromes: Rapid Recognition and Perioperative Implications, 2e AB - Deficiency of homogentisic acid oxidase leads to discoloration and staining of tissues. Dark discoloration of the urine when exposed to air should alert the clinician of the possible presence of homogentisic acid. Valvular heart disease and myocardial ischemia may occur in adults. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1164061285 ER -