TY - CHAP M1 - Book, Section TI - Aniridia A1 - Bissonnette, Bruno A1 - Luginbuehl, Igor A1 - Engelhardt, Thomas Y1 - 2019 N1 - T2 - Syndromes: Rapid Recognition and Perioperative Implications, 2e AB - It is estimated that approximately one-third of patients with sporadic aniridia will develop a Wilms tumor (nephroblastoma), while this risk increases to approximately one half of patients if aniridia, genitourinary anomalies (eg, hypospadias), and mental retardation are simultaneously present. The association with genitourinary anomalies and mental retardation is known as ☞WAGR Syndrome. Most patients have prominent lips and macrognathia. Other features may include congenital cataracts, nystagmus, ptosis, and blindness. The presence of ptosis and generalized hypotonia in a subgroup of patients reportedly suggests a susceptibility to malignant hyperthermia. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1164061747 ER -