TY  - CHAP
M1  - Book, Section
TI  - Hyperbilirubinemia: Unconjugated
A1  - Gomella, Tricia Lacy
A1  - Eyal, Fabien G.
A1  - Bany-Mohammed, Fayez
Y1  - 2020
N1  - 
T2  - Gomella's Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 8e
AB  - When  the  rate  of  bilirubin  production  exceeds  the  rate  of  elimination,  the  end  result  is  a  rise  in  the  total  serum  bilirubin  (TSB),  a  clinical  condition  called  hyperbilirubinemia.  The  accumulation  of  bilirubin  manifests  as  yellow  discoloration  of  the  skin,  sclera,  and  mucosa  called  jaundice.  Neonates  with  severe  hyperbilirubinemia  (defined  as  a  TSB  >25  mg/dL  in  late  preterm  and  term  infants)  are  at  risk  for  bilirubin-induced  neurologic  dysfunction  (BIND),  which  occurs  when  bilirubin  crosses  the  blood–brain  barrier  and  binds  to  targeted  brain  tissues.  Hyperbilirubinemia  presents  as  either  unconjugated  hyperbilirubinemia  or  conjugated  hyperbilirubinemia.  The  2  forms  involve  different  causes  and  complications.  In  contrast  to  unconjugated  hyperbilirubinemia,  which  can  be  transient  and  physiologic  in  the  newborn  period,  conjugated  hyperbilirubinemia  is  always  pathologic  and  requires  thorough  investigation.  See  Chapter  98  for  a  discussion  of  conjugated  hyperbilirubinemia  (direct)  and  Chapters  62  and  63  for  rapid  “on-call”  assessment  and  management  of  the  2  conditions.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1168357694
ER  -