TY  - CHAP
M1  - Book, Section
TI  - Immunodeficiency
A1  - Abbott, Jordan K.
A1  - Dutmer, Cullen M.
A1  - Hauk, Pia J.
A2  - Bunik, Maya
A2  - Hay, William W.
A2  - Levin, Myron J.
A2  - Abzug, Mark J.
Y1  - 2022
N1  - 
T2  - Current Diagnosis & Treatment: Pediatrics, 26e
AB  - Immunodeficiency  is  a  physiologic  state  in  which  the  immune  system  succumbs  to  microbiologic  exposures  typically  controlled  by  members  of  the  nonimmunodeficient  population.  This  state  can  be  transient  or  persistent,  in-born  or  acquired,  and  it  can  result  from  dysfunction  of  one  or  multiple  components  of  the  immune  system.  The  infectious  manifestations  of  immunodeficiency  arise  from  a  failure  to  prevent,  clear,  limit  the  spread,  or  suppress  a  microorganism  that  would  typically  be  controlled  in  one  of  the  modes  of  defense.  Clinical  manifestations  therefore  include  infection  with  an  unusual  microorganism,  greater  extent  of  spread  of  an  infection,  persistent  infection,  recurrent  infection,  and  the  associated  inflammatory  consequences  of  these  scenarios.  Since  infections  in  immunodeficiency  are  dependent  on  a  relevant  microbiologic  exposure,  it  is  possible  that  immunodeficiency  can  remain  undiagnosed;  however,  careful  consideration  of  associated  features,  family  history,  immunosuppressive  medications,  and  laboratory  findings  can  hasten  the  diagnosis  and  possibly  prevent  a  severe  infection  or  other  complication.  As  a  result,  it  is  important  that  physicians  be  aware  of  clues  that  could  lead  to  a  prompt  diagnosis.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1190368494
ER  -