TY - CHAP M1 - Book, Section TI - Chapter 59. Bronchopulmonary Dysplasia A1 - Jobe, Alan H. A2 - Rudolph, Colin D. A2 - Rudolph, Abraham M. A2 - Lister, George E. A2 - First, Lewis R. A2 - Gershon, Anne A. Y1 - 2011 N1 - T2 - Rudolph's Pediatrics, 22e AB - Bronchopulmonary dysplasia (BPD) was described by Northway and colleagues1 in 1967 as a syndrome of severe lung injury in preterm infants who had received mechanical ventilation and high levels of supplemental oxygen. This initial description of BPD occurred in the era when mechanical ventilation was just beginning to be used for preterm infants and the mean birth weight of the infants who survived mechanical ventilation to develop BPD was 2.3 kg. The pathology was characterized by prominent airway injury, epithelial metaplasia, smooth muscle hypertrophy, and parenchymal fibrosis alternating with emphysema. The experimental work during that era demonstrated that the causes of BPD were primarily mechanical ventilation of and oxygen exposure to the developing lung.2 SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=6736436 ER -