TY  - CHAP
M1  - Book, Section
TI  - Chapter 171. Multifactorial Inheritance
A1  - Jorde, Lynn B.
A2  - Rudolph, Colin D.
A2  - Rudolph, Abraham M.
A2  - Lister, George E.
A2  - First, Lewis R.
A2  - Gershon, Anne A.
Y1  - 2011
N1  - 
T2  - Rudolph's Pediatrics, 22e
AB  - Although  the  genetics  of  most  single-gene  disorders  are  now  quite  well  understood,  these  disorders  account  for  a  relatively  small  proportion  of  the  total  disease  burden  in  the  pediatric  population  compared  with  diseases  that  are  thought  to  arise  from  the  interaction  of  multiple  genetic  and  environmental  factors.  Examples  of  the  latter  include  neural  tube  defects,  congenital  heart  defects,  isolated  cleft  lip/palate,  and  clubfoot.  Many  multifactorial  disorders  are  present  at  birth  and  are  thus  considered  to  be  congenital  malformations,  but  others,  such  as  infantile  autism  and  type  1  diabetes,  typically  present  later  in  childhood.  This  section  will  review  basic  concepts  relating  to  the  genetics  of  multifactorial  disorders,  with  emphasis  on  diseases  that  occur  in  the  pediatric  population.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/16
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=6728549
ER  -