TY - CHAP M1 - Book, Section TI - Chapter 245. Antiviral Therapy A1 - Hong, David K. A1 - Prober, Charles G. A2 - Rudolph, Colin D. A2 - Rudolph, Abraham M. A2 - Lister, George E. A2 - First, Lewis R. A2 - Gershon, Anne A. Y1 - 2011 N1 - T2 - Rudolph's Pediatrics, 22e AB - Advances in molecular virology, with the identification of viral-specific enzymes, led to the development of a number of antiviral agents. Effective antivirals currently are available for the management of infections caused by herpes simplex virus (HSV), varicella-zoster virus (VZV), cytomegalovirus (CMV), hepatitis B and C viruses, influenza A and B viruses, and human immunodeficiency virus (HIV). To maximize therapeutic efficacy, treatment should be initiated as early in the course of infection as possible. Under some circumstances (eg, recurrent herpes simplex virus infections and exposure to influenza virus), antivirals may be effective in the prevention of infection. Development of resistance to antivirals is emerging as a problem, especially in the immunocompromised host population and more recently with influenza viruses circulating in the general population. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/10/11 UR - accesspediatrics.mhmedical.com/content.aspx?aid=7024440 ER -