TY  - CHAP
M1  - Book, Section
TI  - Chapter 305. Arboviruses
A1  - Brophy, Jason
A1  - Ford-Jones, Elizabeth Lee
A2  - Rudolph, Colin D.
A2  - Rudolph, Abraham M.
A2  - Lister, George E.
A2  - First, Lewis R.
A2  - Gershon, Anne A.
Y1  - 2011
N1  - 
T2  - Rudolph's Pediatrics, 22e
AB  - Arboviruses  (or  arthropod-borne  viruses)  are  a  heterogeneous  group  of  viruses  that  share  the  same  usual  route  of  entry  into  humans:  via  the  bite  of  an  infected  mosquito,  tick,  sandfly,  or  other  arthropod.1,2  The  life  cycle  of  most  arboviruses  is  characterized  by  the  ability  of  the  virus  to  replicate  in  both  an  arthropod  vector  and  a  vertebrate  “natural”  host  (usually  birds  or  small  mammals)  and  by  transmission  between  these  two  organisms  at  the  time  of  the  arthropod’s  bite  (eFig.  305.1).  This  cycle  leads  to  establishment  or  maintenance  of  the  virus  in  a  given  ecosystem.  Humans  or  domestic  animals  are  only  “incidental”  hosts  for  many  species  of  arboviruses,  as  infection  in  such  hosts  (although  capable  of  causing  disease)  is  often  a  dead-end  for  the  virus  due  to  viremia  being  too  low  or  too  transient  to  contribute  to  maintenance  of  the  cycle  of  transmission.  Some  viruses  are  specific  to  a  single  genus  or  species  of  insect,  while  others  are  transmissible  by  multiple  vectors.  In  addition,  some  arthropods  are  capable  of  transovarial  transmission,  wherein  their  eggs  (which  sometimes  overwinter  and  hatch  in  spring)  are  infected  with  the  virus,  allowing  viral  maintenance  in  areas  of  colder  climate.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=7029250
ER  -