TY  - CHAP
M1  - Book, Section
TI  - Chapter 454. Ewing Sarcoma and Primitive Neuroectodermal Tumor
A1  - Mackall, Crystal L.
A1  - Toretsky, Jeffrey A.
A2  - Rudolph, Colin D.
A2  - Rudolph, Abraham M.
A2  - Lister, George E.
A2  - First, Lewis R.
A2  - Gershon, Anne A.
Y1  - 2011
N1  - 
T2  - Rudolph's Pediatrics, 22e
AB  - Ewing  sarcoma  (ES)  is  the  second  most  common  bone  tumor  in  children  and  adolescents.  It  was  named  for  James  Ewing,  a  pathologist  who  first  described  the  tumor  in  1921,  emphasizing  its  distinction  from  osteosarcoma  based  upon  enhanced  radiosensitivity  and  a  propensity  to  involve  flat  bones  of  the  axial  skeleton.1  In  the  early  1980s,  both  Ewing  sarcoma  and  peripheral  primitive  neuroectodermal  tumor  (PNET)  were  found  to  contain  identical  t(11;22)(q24;q12)  translocations.2,3  Based  upon  the  shared  translocation,  and  similar  clinical  behaviors,  Ewing  Sarcoma  Family  of  Tumors  (ESFT)  is  now  considered  one  disease  entity  that  includes  classical  ES,  atypical  ES,  peripheral  primitive  neuroectodermal  tumor,  neuroepithelioma,  and  Askin  tumor  (an  ESFT  of  the  chest  wall).  It  should  be  emphasized  that  peripheral  PNETs  are  entirely  different  from  PNETs  arising  in  the  central  nervous  system  which  do  not  bear  the  t(11;22)  translocation  and  are  not  considered  part  of  the  ESFT  category.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/25
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=7043301
ER  -