TY - CHAP M1 - Book, Section TI - Chapter 508. Disorders of Respiratory Control and Sleep-Disordered Breathing A1 - Gozal, David A1 - Kheirandish-Gozal, Leila A2 - Rudolph, Colin D. A2 - Rudolph, Abraham M. A2 - Lister, George E. A2 - First, Lewis R. A2 - Gershon, Anne A. Y1 - 2011 N1 - T2 - Rudolph's Pediatrics, 22e AB - While the neuronal and musculoskeletal components of the respiratory system mature postnatally, the systems governing respiratory control in general, and more specifically rhythmogenesis, must be mature and functional by birth to enable the successful transition from fetus to infant. The respiratory controllers must have the necessary components to generate a rhythm that allows gas exchange in a highly compliant chest wall and to integrate swallowing, crying, vocalization, and other behaviors with breathing. Neonatal intensive care units are a frequent place where pediatricians are daily confronted with immature respiratory control systems. Premature infants display deficiencies of central respiratory rhythmogenesis or of activation of respiratory musculature. However, such problems are not restricted to this particular stage of life, and alterations in the control of breathing may play a role in many conditions that become apparent throughout childhood and adolescence, particularly during sleep. During sleep, the clinical manifestations of many diseases of respiratory control as well as other conditions affecting the respiratory system in general are more likely to emerge. Thus, understanding the pathogenesis of breathing problems is an important component of the clinical evaluation of any child with respiratory symptoms. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=7050456 ER -