TY  - CHAP
M1  - Book, Section
TI  - Chapter 539. Disorders of Sexual Development (DSD)
A1  - Grumbach, Melvin M.
A2  - Rudolph, Colin D.
A2  - Rudolph, Abraham M.
A2  - Lister, George E.
A2  - First, Lewis R.
A2  - Gershon, Anne A.
Y1  - 2011
N1  - 
T2  - Rudolph's Pediatrics, 22e
AB  - Abnormalities  of  sex  differentiation  or  disorders  of  sexual  development  (DSD)  are  divided  into  two  broad  categories:  (1)  errors  in  (primary)  sex  determination,  such  as  sex  chromosome  anomalies  and  gene  mutations  that  interrupt  or  disrupt  normal  gonadogenesis,  which  lead  to  abnormalities  of  gonadogenesis,  and  (2)  errors  in  sex  differentiation  that  cause  abnormal  development  of  the  somatic  sex  structures—the  genital  ducts,  urogenital  sinus,  and  external  genitalia.  Intrinsic  or  extrinsic  factors  that  adversely  affect  any  of  the  stages  of  these  mechanisms  can  cause  anomalies  of  sexual  structure.  Table  539-1  presents  the  consensus  Classification  of  Disorders  of  Sex  Development  for  clinical  use.  Older  terminology  used  for  classification  (shown  in  parentheses  in  Table  539-1)  have  been  abandoned  and  replaced  by  newer  designations.1,2  The  management  approach  to  these  disorders,  including  discussion  of  gender  determination,  is  discussed  in  the  final  section  of  this  chapter.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=7054336
ER  -