TY  - CHAP
M1  - Book, Section
TI  - Section 14. Bullous, Pustular, and Ulcerating Diseases
A1  - Weinberg, Samuel
A1  - Prose, Neil S.
A1  - Kristal, Leonard
Y1  - 2008
N1  - 
T2  - Color Atlas of Pediatric Dermatology, 4e
AB  - Pemphigus  vulgaris  is  a  rare  autoimmune,  bullous  disease  that  occasionally  occurs  during  childhood.  The  disease  affects  both  the  skin  and  mucous  membranes  and  can  be  life  threatening.  The  typical  lesions  of  pemphigus  vulgaris  are  pictured  here.  Erosions  of  the  lips,  gums,  tongue,  and  palate,  as  pictured  in  Fig.  14-1,  are  a  common  presenting  symptom  and  may  be  misdiagnosed  early  in  the  course  of  the  disease.  The  difficulty  in  chewing  and  swallowing  that  may  occur  can  become  a  significant  complication.  Cutaneous  lesions  consist  of  flaccid  weeping  blisters  that  quickly  erode  to  leave  large  denuded  areas  of  skin.  Nikolsky's  sign,  the  extension  of  blistering  by  lateral  finger  pressure,  is  seen  in  the  presence  of  widespread  disease.  Figure  14-2  shows  the  kind  of  crusting  that  develops  as  the  roofs  of  blisters  of  pemphigus  vulgaris  disintegrate.  Antibodies  to  desmoglein  1  are  associated  with  skin  lesions  and  antibodies  to  desmoglein  3  are  associated  with  oral  lesions.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/16
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=6988246
ER  -