TY - CHAP M1 - Book, Section TI - Chronic Pancreatitis in the Pediatric Population A1 - Bondoc, Alex A1 - Tiao, Greg M. A2 - Ziegler, Moritz M. A2 - Azizkhan, Richard G. A2 - Allmen, Daniel von A2 - Weber, Thomas R. Y1 - 2014 N1 - T2 - Operative Pediatric Surgery, 2e AB - An unremitting, deranged inflammatory response characterizes chronic pancreatitis (CP) in children and is modulated by environmental and genetic factors.Unlike adults, the etiology of pediatric CP involves congenital or anatomic variants, genetic mutations, or autoimmune disease.The diagnostic work-up of children suspected to have CP should include sweat chloride assessment, genetic assay for CFTR, SPINK1, and PRSS mutations, endoscopic and/or radiographic imaging, and autoimmune testing.Initial therapy for CP includes treatment for symptoms including pain and endocrine and/or exocrine insufficiency. However, more invasive endoscopic or surgical therapy may be necessary and is often predicated on degrees of ductal obstruction and parenchymal disease. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/05 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1100952828 ER -