TY  - CHAP
M1  - Book, Section
TI  - Psychotherapeutic Drugs
A1  - Meehan, Timothy J.
A1  - Marcucci, Jared J.
A2  - Schafermeyer, Robert
A2  - Tenenbein, Milton
A2  - Macias, Charles G.
A2  - Sharieff, Ghazala Q.
A2  - Yamamoto, Loren G.
Y1  - 2014
N1  - 
T2  - Strange and Schafermeyer's Pediatric Emergency Medicine, 4e
AB  - The  key  targets  of  antidepressant  and  neuroleptic  poisoning  are  the  cardiovascular  and  central  nervous  systems.Tricyclic  antidepressant  poisoning  is  potentially  life  threatening  due  to  ventricular  dysrhythmias  and  hypotension.  Treatment  is  supportive  with  consideration  given  to  sodium  bicarbonate  for  dysrhythmia  prevention  and  treatment,  and  to  pressors  for  hypotension.Children  who  are  asymptomatic  for  6  hours  after  the  ingestion  of  antidepressants  or  neuroleptics  may  be  discharged  from  the  ED.The  serotonin  syndrome  (SS)  is  a  life-threatening  condition  manifested  by  mental  status  changes,  autonomic  instability,  hyperthermia,  and  neuromuscular  abnormalities  such  as  hyperreflexia  and  tremors.  Its  treatment  is  supportive  with  consideration  given  to  cyproheptadine.The  neuroleptic  malignant  syndrome  (NMS)  is  a  life-threatening  condition  manifested  by  hyperthermia,  skeletal  muscle  rigidity,  and  altered  mental  status.  Its  treatment  is  supportive  with  particular  attention  to  cooling  and  consideration  given  to  bromocriptine.Overdose  of  typical  neuroleptics  may  produce  an  acute  dystonic  reaction,  which  can  be  reversed  with  diphenhydramine  or  benztropine  mesylate.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1105686735
ER  -