TY - CHAP M1 - Book, Section TI - Oral Anti-Diabetic Agents A1 - Barker, Kimberly A1 - Seger, Donna A2 - Schafermeyer, Robert A2 - Tenenbein, Milton A2 - Macias, Charles G. A2 - Sharieff, Ghazala Q. A2 - Yamamoto, Loren G. Y1 - 2014 N1 - T2 - Strange and Schafermeyer's Pediatric Emergency Medicine, 4e AB - Oral anti-diabetic drugs function by either increasing insulin secretion or by modulating blood glucose concentrations through a variety of mechanisms other than the increase of blood insulin concentration.Significant poisoning is associated with sulfonylureas and metformin only.Sulfonylurea overdose can produce life-threatening hypoglycemia, and the antidote of choice is octreotide.It is inadvisable to administer prophylactic intravenous dextrose to normoglycemic children with sulfonylurea ingestion because this may mask and prolong the appearance of sulfonylurea-induced hypoglycemia.Asymptomatic, euglycemic young children presenting with a history of sulfonylurea ingestion require 8 hours of observation and no prophylactic intravenous dextrose therapy.Metformin overdose can result in life-threatening lactic acidosis that may require hemodialysis. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/13 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1105686825 ER -