TY - CHAP M1 - Book, Section TI - Syphilis A1 - Gomella, Tricia Lacy A1 - Cunningham, M. Douglas A1 - Eyal, Fabien G. A1 - Tuttle, Deborah J. Y1 - 2013 N1 - T2 - Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 7e AB - Syphilis is a sexually transmitted infection caused by Treponema pallidum, which is a thin, motile spirochete that is extremely fastidious, surviving only briefly outside the host. According to the Centers for Disease Control and Prevention (CDC), a case of congenital syphilis (CS) is defined as illness in an infant from whom lesional, placental, umbilical cord, or autopsy material specimens demonstrated T. pallidum by dark-field microscopy, fluorescent antibody, or other specific stain; an infant whose mother had untreated or inadequately treated syphilis at delivery (ie, any nonpenicillin therapy or penicillin administered <30 days before delivery); or an infant or child who has a reactive treponemal test for syphilis and any of the following: evidence of CS on physical examination, evidence of CS on radiographs of long bones, reactive cerebrospinal fluid (CSF) venereal disease research laboratory test (VDRL), elevated CSF cell count or protein (without other causes) or a reactive fluorescent treponemal antibody absorbed–19S-immunoglobulin M (IgM) antibody test or IgM enzyme-linked immunosorbent assay. This definition includes infants who are stillborn to women with untreated syphilis. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1107525494 ER -