TY - CHAP M1 - Book, Section TI - Parenteral Nutrition A1 - Adamkin, David H. A2 - Stevenson, David K. A2 - Cohen, Ronald S. A2 - Sunshine, Philip Y1 - 2015 N1 - T2 - Neonatology: Clinical Practice and Procedures AB - Total parenteral nutrition (TPN) as used today in the neonatal intensive care unit (NICU) became a part of modern medicine in the late 1960s. Dudrick et al, in groundbreaking work, first demonstrated in beagle puppies the technique for parenterally administering nutrients.1 Shortly thereafter, Wilmore and Dudrick2 reported the use of this technique in an infant who had virtually no remaining small intestine and was totally dependent on these parenterally delivered nutrients of glucose, fibrin hydrolysate, minerals, and vitamins. There were no intravenous fat emulsions available, so plasma was given in small aliquots to provide some essential fatty acids (EFAs) and trace elements.2 Although this historic patient did not survive, normal growth and development was maintained for several months solely on this primitive solution. By the early 1970s, the technique was being used extensively in infants and children with congenital or acquired surgically correctable lesions of the gastrointestinal tract3,4 and in infants with intractable diarrhea.4,5 Use in the low birth weight infant soon followed.4,6,7 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1109791717 ER -