TY - CHAP M1 - Book, Section TI - Teratogenicity of Antiepileptic Drugs A1 - Gaily, Eija A1 - Lindhout, Dick A2 - Duchowny, Michael A2 - Cross, J. Helen A2 - Arzimanoglou, Alexis PY - 2017 T2 - Pediatric Epilepsy AB - In most women with epilepsy, it is necessary to continue antiepileptic drug (AED) treatment during pregnancy to reduce the risks caused by epileptic seizures for both mother and child.1,2,3 The risk of maternal death during pregnancy has been estimated to be ten times higher in women with epilepsy compared to the general population,4 possibly due to poor compliance with AED treatment and seizure occurrence. Seizure-related accidents and convulsive status epilepticus during pregnancy are associated with an increased risk of fetal death.5 Even brief generalized tonic–clonic seizures during pregnancy may have an unfavorable effect on cognitive outcome based on retrospective data,4 although this has not been confirmed prospectively.6,7 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1138412327 ER -