TY  - CHAP
M1  - Book, Section
TI  - Adrenal Insufficiency
A1  - White, Perrin C.
A1  - Sarafoglou, Kyriakie
A2  - Sarafoglou, Kyriakie
A2  - Hoffmann, Georg F.
A2  - Roth, Karl S.
PY  - 2017
T2  - Pediatric Endocrinology and Inborn Errors of Metabolism, 2e
AB  - Primary  adrenal  insufficiency  (PAI)  results  from  destruction  or  dysfunction  of  the  adrenal  cortex;  50%  to  70%  of  cases  presenting  in  infancy  or  childhood  represent  specific  enzymatic  defects  in  corticosteroid  biosynthesis,  collectively  termed  congenital  adrenal  hyperplasia  (CAH;  see  Chapter  29).  CAH  occurs  in  1:16,000  newborns  in  most  populations,  corresponding  to  an  incidence  of  ~1/300,000  if  counting  all  children  younger  than  18  years.  Therefore  the  incidence  of  other  causes  of  adrenal  insufficiency  must  be  similar  to  or  slightly  less  than  this.  Approximately  half  of  the  remaining  non-CAH  cases  are  caused  by  autoimmune  adrenalitis  (Table  28-1).  We  begin  this  section  with  a  general  discussion  of  primary  adrenal  insufficiency,  and  then  consider  specific  etiologies.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1140319277
ER  -