TY - CHAP M1 - Book, Section TI - Endocrine Problems in Pediatric Cancer Survivors A1 - Patterson, Briana C. A1 - Meacham, Lillian R. A2 - Sarafoglou, Kyriakie A2 - Hoffmann, Georg F. A2 - Roth, Karl S. PY - 2017 T2 - Pediatric Endocrinology and Inborn Errors of Metabolism, 2e AB - Survival rates for pediatric cancers continue to improve. Overall 5-year survival for all types has increased from 58.1% for childhood cancers diagnosed in the 1970s to 82.5% for those diagnosed between 2001 and 2007.1,2 As a result, the population of childhood cancer survivors expands, and it is estimated 1:570 young adults living in the United States is a survivor of childhood cancer.3 However, curative cancer treatment comes with a price; radiation, chemotherapy, surgery, and bone marrow transplant (BMT) can all negatively affect endocrine function. In many cases, children are treated with multimodal therapy and may be at risk for multiple endocrine late effects. Complications of cancer therapy may be acute-onset and transient, like weight loss; acute-onset and chronic, like acute ovarian failure; or late in onset, like infertility and hypothyroidism. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/05 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1140324700 ER -