TY - CHAP M1 - Book, Section TI - Leukemia, Chronic Myelogenous (CML) A1 - Hay, Jr, William W. A1 - Levin, Myron J. A1 - Deterding, Robin R. A1 - Abzug, Mark J. PY - 2017 T2 - Quick Medical Diagnosis & Treatment Pediatrics AB - CML with translocation of chromosomes 9 and 22 (the Philadelphia chromosome, Ph+) is identical to adult Ph+CMLTranslocation 9;22 results in the fusion of the BCR gene on chromosome 22 and the ABL gene on chromosome 9The resulting fusion protein is a constitutively active tyrosine kinase that interacts with a variety of effector proteins and allows for deregulated cellular proliferation, decreased adherence of cells to the bone marrow extracellular matrix, and resistance to apoptosisThe disease usually progresses within 3 years to an accelerated phase and then to a blast crisis SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1145456778 ER -