TY - CHAP M1 - Book, Section TI - Infections in Special Hosts A1 - Downes, Kevin J. A1 - Danziger-Isakov, Lara A. A2 - Zaoutis, Lisa B. A2 - Chiang, Vincent W. PY - 2017 T2 - Comprehensive Pediatric Hospital Medicine, 2e AB - The definition of immune compromise is characterized by an impairment of a host’s ability to effectively handle infectious challenges. As new therapeutic options for previously untreatable illnesses become available, a growing number of children fall into this category. This chapter focuses primarily on the infection-related issues among children who are immunocompromised owing to solid organ or hematopoietic cell transplantation; splenic dysfunction will also be addressed. These special hosts may present for the evaluation of unexplained fever, or with focal signs of infection, and often require a different approach than pursued in an otherwise healthy child. The goal of this chapter is to provide the pediatric hospitalist with a framework for infectious diseases evaluation in these children. Infectious complications related to chemotherapy for malignancy are discussed in Chapter 133. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1146119624 ER -