TY - CHAP M1 - Book, Section TI - Hypotonia and Weakness A1 - Yum, Sabrina W. A2 - Zaoutis, Lisa B. A2 - Chiang, Vincent W. PY - 2017 T2 - Comprehensive Pediatric Hospital Medicine, 2e AB - Hypotonia and weakness may signify a variety of systemic, neurologic, and neuromuscular disorders (Table 120-1). Evaluation of hypotonia and weakness can be challenging, as the list of possible diagnoses is extensive and includes many rare conditions. A logical first step in the evaluation is to localize the lesion to the central nervous system (CNS) or the peripheral nervous system (PNS), which frequently can be accomplished by detailed birth and medical history, along with thorough general and neurological examination. Localization will help to narrow the list of differential diagnoses and guide subsequent investigations to reach a specific diagnosis. It is important that pediatric hospitalists are knowledgeable of the general approach to this group of patients, and have a basic understanding of the diagnostic possibilities and their clinical presentations, pathophysiology, diagnosis, and associated morbid conditions as well as management. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/04 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1146120417 ER -