TY  - CHAP
M1  - Book, Section
TI  - Withdrawal Syndromes
A1  - Hoffman, Robert J.
A1  - Sharma, Adhi N.
A2  - Zaoutis, Lisa B.
A2  - Chiang, Vincent W.
PY  - 2017
T2  - Comprehensive Pediatric Hospital Medicine, 2e
AB  - Drug  withdrawal  is  a  physiologic  response  to  an  effectively  lowered  drug  concentration  in  a  patient  tolerant  to  the  drug  in  question.  Withdrawal  results  in  a  predictable  constellation  of  symptoms  that  are  reversible  if  the  drug  is  reintroduced.  Withdrawal  is  a  phenomenon  of  altered  neurochemistry,  and  the  central  nervous  system  (CNS)  is  the  most  consequential  target.  Under  normal  conditions,  the  CNS  maintains  a  balance  between  excitation  and  inhibition.  Although  such  balance  can  be  achieved  by  several  means,  excitation  is  constant  and  actions  occur  through  removal  of  inhibitory  tone.1  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1146123968
ER  -