TY - CHAP M1 - Book, Section TI - Disorders of Pentose Phosphate Pathway A1 - Kishnani, Priya S. A1 - Chen, Yuan-Tsong A2 - Kline, Mark W. PY - 2018 T2 - Rudolph's Pediatrics, 23e AB - About 90% of glucose metabolism in the body occurs via the glycolytic pathway and the remaining 10% via the hexose monophosphate pathway. The hexose monophosphate shunt leads to formation of pentoses and generates NADH. One of the metabolites, ribose-5-phosphate, is used in the biosynthesis of ribonucleotides and deoxyribonucleotides. Through the transketolase and transaldolase reactions, the pentose phosphates can be converted back to fructose-6-phosphate and glucose-6-phosphate. The congenital abnormalities in pentose metabolism include a benign pentosuria and 2 recently described enzyme deficiencies: transaldolase deficiency and ribose-5-phosphate isomerase deficiency. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182929275 ER -