TY - CHAP M1 - Book, Section TI - Clinical Aspects of Allergic Diseases A1 - Anvari, Sara A1 - Garcia-Lloret, Maria A2 - Kline, Mark W. PY - 2018 T2 - Rudolph's Pediatrics, 23e AB - Allergic rhinoconjunctivitis, asthma, and food allergy are some of the prototypical allergic diseases. Whereas allergies may develop at any age, allergic sensitization occurs predominantly early in life. Atopy is the inherited tendency to produce allergen-specific immunoglobulin (Ig) E antibodies. Food-specific IgE antibodies may appear in the very young child to herald an early presentation of clinical food allergies. Environmental allergen-specific IgE antibodies develop mostly after the age of 2, often leading to allergic rhinitis and/or allergic asthma in preschool or school-aged children. Although not all allergic diseases invariably develop in the same patient, in a sizeable number of children, the progressive sensitization to multiple antigens will result in sequential and often cumulative manifestations of atopy, a continuum that is known as the allergic march. It follows that allergic sensitization in childhood can have long-lasting effects throughout the life of the individual and implies a considerable burden to society as a whole. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/12 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182931781 ER -