TY - CHAP M1 - Book, Section TI - Hematopoiesis A1 - Punia, Jyotinder Nain A1 - Elghetany, M. Tarek A2 - Kline, Mark W. PY - 2018 T2 - Rudolph's Pediatrics, 23e AB - The bone marrow, one of the largest organs in the human body, accomplishes the enormous and complex task of blood cell production. In adults, the marrow produces 2.5 billion red cells, 2.5 billion platelets, and 1 billion granulocytes per kilogram of body weight on a daily basis. Blood cell production, which can increase up to 30-fold, depending upon increased peripheral demand or increased destruction, is mediated by complex interactions of marrow stem cells with stromal cells, hematopoietic growth factors, and interleukins. This chapter provides an overview of the developmental changes in hematopoiesis that occur from embryonic development through adolescence, addressing changes in the sites of hematopoiesis, components of peripheral blood, and the type of hemoglobin that is produced. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182909587 ER -