TY - CHAP M1 - Book, Section TI - Overview of the Immune System A1 - Sullivan, Kathleen E. A2 - Kline, Mark W. PY - 2018 T2 - Rudolph's Pediatrics, 23e AB - Our immune system has evolved to provide protection from the pathogens that inhabit the natural world, and a critical aspect of immunologic function is the distinction between self tissues and non-self tissues. Self tissues must not become a target for immune responses, and training to protect self tissues is the essence of tolerance. Our host defense includes barrier functions, and we now know that the barrier interacts dynamically with the cells of the immune system as part of this defense. In this overview, we will describe the elements of the immune system, the development of different functional arms of the immune system, and the beautiful choreography that is intrinsic to an immune response. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/25 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182931515 ER -