TY  - CHAP
M1  - Book, Section
TI  - The Biliary Tract
A1  - Bass, Lee M.
A1  - Fishman, Douglas S.
A2  - Kline, Mark W.
PY  - 2018
T2  - Rudolph's Pediatrics, 23e
AB  - In  the  human  embryo  the  first  anlage  of  the  bile  ducts  and  liver  is  the  hepatic  diverticulum  from  the  proximal  gastrointestinal  tract,  as  described  in  Chapter  413.  The  caudal  part  of  this  bud,  known  as  the  pars  cystica,  grows  in  length  and  forms  the  gallbladder,  cystic  duct,  and  common  bile  duct.  At  about  the  eighth  week  of  gestation,  the  hepatic  precursor  cells  that  lie  adjacent  to  the  hilar  portal  vein  vessels  form  a  sleeve-like  double  layer  of  cells  that  extends  toward  the  periphery  along  the  smaller  intrahepatic  portal  vein  branches.  These  hepatoblasts  strongly  express  biliary-specific  cytokeratins  and  can  be  considered  biliary  precursor  cells,  which  then  form  a  continuous  single-layered  ring  around  the  portal  mesenchyme,  known  as  the  ductal  plate.  Beginning  at  12  weeks  of  gestation  and  extending  into  the  postnatal  period,  the  ductal  plate  undergoes  progressive  remodeling.  As  new  ductules  form,  they  are  incorporated  into  the  periportal  mesenchyme  that  surrounds  the  portal  vein  branches.  Thus,  during  successive  periods  of  fetal  life,  ductal  plate  remodeling  leads  to  the  formation  of  the  intrahepatic  biliary  tree.  The  largest  ducts  are  formed  first,  followed  by  segmental,  interlobular,  and,  finally,  the  smallest  bile  ductules.  Arrest  or  derangement  in  remodeling  leads  to  the  persistence  of  primitive  bile  duct  configurations  termed  ductal  plate  malformations.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1182909445
ER  -