TY - CHAP M1 - Book, Section TI - Histiocytic Disorders A1 - Eckstein, Olive A1 - Allen, Carl A1 - McClain, Kenneth A2 - Kline, Mark W. PY - 2018 T2 - Rudolph's Pediatrics, 23e AB - Histiocytic disorders arise from abnormal development or function of histiocytes, which literally means “tissue cells.” However, we remain loyal to the archaic nomenclature for histiocytosis that is meant to encompass all cells of the mononuclear phagocytic system. The histiocytic umbrella therefore covers a wide range of disorders, from physiologic reaction to inflammatory stimuli to dysregulated differentiation and proliferation. This chapter will focus on the most common histiocytic disorders in children, including Langerhans cell histiocytosis (LCH), juvenile xanthogranuloma (JXG), Rosai-Dorfman disease, and hemophagocytic lymphohistiocytosis (HLH). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182911833 ER -