TY - CHAP M1 - Book, Section TI - Disorders of Digestion and Absorption A1 - Ediger, Tracy R. A1 - Hill, Ivor D. A2 - Kline, Mark W. PY - 2018 T2 - Rudolph's Pediatrics, 23e AB - The assimilation of ingested nutrients involves a complex integrated process of digestion and absorption with subsequent transport of the breakdown products across the intestinal mucosa into the systemic circulation. Normal digestion and absorption are discussed in Chapter 376. The term malabsorption is broadly used to characterize abnormalities of both digestion and absorption. The schema in Table 403-1 lists the major pathogenic mechanisms of various specific malabsorptive disorders that generally are due to disorders in luminal digestion, mucosal function, or lymphatic transport. Malabsorption may involve multiple nutrients (as occurs with celiac disease or pancreatic insufficiency) or only a single molecule (as found in isolated glucose-galactose malabsorption or vitamin B12 malabsorption). Defects may be congenital, with onset of symptoms shortly after birth, or acquired, when the age of onset of symptoms is variable. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/24 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182908310 ER -