TY - CHAP M1 - Book, Section TI - Brain Tumors and Spinal Tumors A1 - Cohen, Kenneth J. A1 - Pollack, Ian F. A2 - Kline, Mark W. PY - 2018 T2 - Rudolph's Pediatrics, 23e AB - Central nervous system (CNS) neoplasms are, as a group, the most common solid tumors of childhood, second only to the leukemias as a cause of cancer in children. Despite improvements in diagnosis and management, more children will die of brain tumors than of any other type of pediatric cancer. Although the prognosis for children with certain CNS tumors, such as medulloblastoma, has been improved through a combination of surgical advances and refinements in radiotherapy and chemotherapy, other groups, such as those with diffuse intrinsic pontine gliomas (DIPGs), continue to have a poor outcome. Children who experience long-term survival after therapy are at risk for sequelae from the tumor or its treatment that may adversely impact their quality of life. Current cooperative group studies are attempting to address these issues, focusing on improving survival results in children with tumor types that historically have been resistant to therapy, as well as on improving quality of life for children with treatment-responsive tumors. Increasingly, these studies also incorporate new insights regarding molecular subsets of tumors to facilitate risk-adapted treatment stratification. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182911673 ER -