TY - CHAP M1 - Book, Section TI - Normal and Abnormal Hemostasis A1 - Paredes, Nethnapha A1 - Berry, Leslie R. A1 - Chan, Anthony K. C. A2 - Kline, Mark W. PY - 2018 T2 - Rudolph's Pediatrics, 23e AB - The hemostatic mechanism is a dynamic system that maintains the fluidity of blood while allowing for the formation of blood clots to prevent bleeding subsequent to blood vessel injury. These interrelated components consist of vessel walls (including endothelial cells), platelets, coagulation factors, inhibitors, and the fibrinolytic mechanism. Perturbation of any of these systems can lead to disease states that are thrombotic or hemorrhagic in nature. This chapter discusses the normal and abnormal hemostatic system in children, with emphasis on disorders involving the endothelium, platelets, and defects in coagulation and fibrinolysis. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/04 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182910042 ER -