TY - CHAP M1 - Book, Section TI - Glomerular Diseases A1 - Wenderfer, Scott E. A1 - Eddy, Allison A. A2 - Kline, Mark W. PY - 2018 T2 - Rudolph's Pediatrics, 23e AB - Glomerular diseases present clinically in several different ways depending on the nature and severity of the primary disease and the extent to which the normal physiologic functions of the glomerulus are perturbed. Some children with glomerulopathies are found incidentally to have microscopic hematuria or proteinuria but are otherwise asymptomatic. At the other extreme, children may become critically ill with oligoanuric rapidly progressive glomerulopathy in need of urgent dialysis. Whereas numerous glomerular diseases are inherited (see Chapter 469), most forms are acquired and are generally considered to be immunologically mediated. There are 3 classical clinical syndromes that develop from glomerular injury: acute and chronic glomerulonephritis (GN), defined by the triad of hematuria, hypertension, and acute kidney injury (AKI); nephrotic syndrome (NS), defined by proteinuria and hypoalbuminemia; and hemolytic-uremic syndrome (HUS), defined by microangiopathic hemolytic anemia, thrombocytopenia, and AKI. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182912708 ER -