TY - CHAP M1 - Book, Section TI - Disorders of Respiratory Control and Sleep-Disordered Breathing A1 - Gozal, David A1 - Kheirandish-Gozal, Leila A2 - Kline, Mark W. PY - 2018 T2 - Rudolph's Pediatrics, 23e AB - The neuronal and musculoskeletal components of the respiratory system mature postnatally, whereas the systems governing respiratory control in general, and more specifically rhythmogenesis, must be mature and functional by birth to enable the successful transition from fetus to infant. In newborn infants, whose chest wall is highly compliant, rhythmical respiration must be coordinated with other behaviors including sucking, swallowing, crying, and other vocalizations. Premature infants display deficiencies of central respiratory rhythmogenesis or of activation of respiratory musculature. However, such problems are not restricted to this particular stage of life, and alterations in the control of breathing may play a role in many conditions that become apparent throughout childhood and adolescence, particularly during sleep. During sleep, the clinical manifestations of many diseases of respiratory control as well as other conditions affecting the respiratory system in general are more likely to emerge. Thus, understanding the pathogenesis of breathing problems is an important component of the clinical evaluation of any child with respiratory symptoms. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1182915762 ER -