TY - CHAP M1 - Book, Section TI - Complex Disease/Deficiency: An Overview A1 - Bissonnette, Bruno A1 - Luginbuehl, Igor A1 - Engelhardt, Thomas PY - 2019 T2 - Syndromes: Rapid Recognition and Perioperative Implications, 2e AB - Complex disorder or mitochondrial disease comprises a steadily growing group of genetically and clinically heterogenous enzyme-complex defects characterized by altered energy metabolism (mitochondrial oxidative phosphorylation) and a wide range of neurological, cardiac, muscular, and endocrine disorders. The system of oxidative phosphorylation is composed of the respiratory chain multi-protein enzyme complexes I-V and the two electron-carriers coenzyme Q (CoQ or ubiquinone) and cytochrome c. The symptoms associated with mitochondrial disease are primarily due to a lack of energy in tissues and thus organs with the highest energy requirements suffer first and foremost. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1164066319 ER -